Improved titanium and steel implants: Studies on bisphosphonate, strontium and surface treatments
نویسنده
چکیده
....................................................................................................................................7 POPULÄRVETENSKAPLIG SAMMANFATTNING...................................................................9 LIST OF PAPERS........................................................................................................................ 11 MY CONTRIBUTIONS TO INCLUDED PAPERS.................................................................... 12 INTRODUCTION........................................................................................................................ 13 Bone .....................................................................................................................................................................13 Wound healing around bone implants ..........................................................................................15 Bone-implant interface............................................................................................................................17 Bioinert fixation .........................................................................................................................................18 Biological fixation......................................................................................................................................18 Bioactive fixation.......................................................................................................................................19 Blood plasma-implant interface ........................................................................................................20 Coagulation at artificial surfaces........................................................................................................20 Immune complement system ..............................................................................................................20 Immune complement activation by biomaterials......................................................................22 Biomaterials ...................................................................................................................................................24 Bone anchored implants ........................................................................................................................24 Bioceramics ..................................................................................................................................................25 Implant surface treatments and improved osseointegration .........................................26 Surface modifications to improve early bone fixation ............................................................26 Sol-gel derived titania coating.............................................................................................................28 Controlled drug delivery by biomaterials ...................................................................................29 Bisphosphonate..........................................................................................................................................31 Strontium ranelate....................................................................................................................................32 AIMS OF THESIS........................................................................................................................ 35 SUMMARY OF MATERIALS..................................................................................................... 37 Implant screws ..............................................................................................................................................37 Silica.....................................................................................................................................................................38 Surface coatings............................................................................................................................................38 TiO2 coating by physical vapor deposition (PVD)......................................................................38 Crosslinked fibrinogen coating...........................................................................................................38 Sol-gel derived titania coating.............................................................................................................39 Calcium phosphate coating...................................................................................................................39 Simulated body fluid (SBF).....................................................................................................................39 Bisphosphonate............................................................................................................................................40 Strontium ranelate .....................................................................................................................................41 Blood plasma, buffers and antibodies............................................................................................41
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